A recent study published in the journal Neurology has found a link between fluctuating blood lipid levels, particularly total cholesterol, and an increased risk of developing Alzheimer’s disease or Alzheimer’s disease-related dementia (ADRD) in the future. The study examined nearly 11,700 adults with an average age of 71.
The research revealed that individuals with the highest levels of total cholesterol variability over a five-year period had a 19% higher risk of developing Alzheimer’s disease or ADRD within the next 12 years. The findings highlight the importance of addressing modifiable risk factors and promoting healthy behaviors to reduce the risk of cognitive decline and potentially protect cognitive health.
Christopher Weber, Director of Global Science Initiatives at the Alzheimer’s Association, noted that this study contributes to the growing body of evidence supporting the role of modifiable risk factors in reducing the risk of cognitive decline and dementia. Weber emphasized the importance of preventive strategies for Alzheimer’s and related dementias.
Lead author Suzette J. Bielinski, a genetic epidemiologist at the Mayo Clinic in Minnesota, highlighted the need for routine screenings of cholesterol and triglyceride levels as part of standard medical care. Fluctuations in lipid levels could serve as indicators of dementia risk and help improve our understanding of the mechanisms behind dementia development. By identifying these fluctuations and potentially leveling them out, it may be possible to reduce the risk of developing Alzheimer’s disease or ADRD.
These findings underscore the significance of maintaining healthy blood lipid levels and adopting lifestyle choices that promote cardiovascular health to potentially mitigate the risk of Alzheimer’s disease and related dementias.